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Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

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By detecting the expression changes in sex-hormone-related genes (such as estrogen receptor genes, androgen receptor genes, etc.) (Wu et al., 2017), we will deeply analyze the differences in the regulation of these gene expressions among sex, reveal sex-specific molecular mechanisms in the pathogenesis of AOP, and provide a strong theoretical basis for the screening of targeted treatment targets